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Blood Nov , 21 ;. So far, lymphocytosis has remained stable and the patient is regularly followed without any need for treatment. This somatic mutation was previously detected in diverse human cancers, with a particularly high frequency in melanoma Nature. In May , we evaluated this patient in Pavia. Hairy cell leukemia HCL is an indolent neoplasm of small mature B-lymphoid cells, which are found in peripheral blood and bone marrow BM , and are characterized by hairy projections of their abundant cytoplasm.